Abstract
Erythroid cells and megakaryocytes are derived from a common precursor, the megakaryocyte-erythroid progenitor. Although these 2 closely related hematopoietic cell types share many transcription factors, there are several key differences in their regulatory networks that lead to differential gene expression downstream of the megakaryocyte-erythroid progenitor. With the advent of next-generation sequencing and our ability to precisely define transcription factor chromatin occupancy in vivo on a global scale, we are much closer to understanding how these 2 lineages are specified and in general how transcription factor complexes govern hematopoiesis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Differentiation / genetics
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Cell Differentiation / physiology
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Cell Lineage / genetics
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Cell Lineage / physiology
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Erythroid Cells* / metabolism
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Gene Regulatory Networks / physiology*
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Hematopoiesis / genetics*
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Hematopoiesis / physiology
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Humans
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Megakaryocyte-Erythroid Progenitor Cells / metabolism
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Megakaryocyte-Erythroid Progenitor Cells / physiology*
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Megakaryocytes / metabolism
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Megakaryocytes / physiology*
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Models, Biological
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Transcription Factors / genetics*
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Transcription Factors / metabolism
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Transcription Factors / physiology