The paper is concerned with the results of single-photon emission tomography and gamma-topography in patients with cerebral tumors, cerebral circulatory disorders and pathology of the liquor system. Tomographic investigation was shown to enhance the accuracy and reliability of the detection of cerebral tumors. Single-photon emission computerized gamma-tomography (SPECT) permitted the detection of structural and morphological cerebral changes in disturbed cerebral circulation of various etiology. SPECT together with computerized tomography and radionuclide cisternography was shown to be an auxiliary method for visualization of the cerebral cisterns. Radionuclide tomographic images as compared to gamma-topographic findings of the brain possessed a high statistical significance and good resolution.