Abstract
A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Crystallography, X-Ray
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DNA, Superhelical / metabolism
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Humans
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Magnetic Resonance Spectroscopy
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Methane / analogs & derivatives*
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Methane / chemical synthesis
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Methane / chemistry
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Methane / pharmacology
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Models, Molecular
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Neoplasms / drug therapy
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology*
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Stereoisomerism
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Sulfhydryl Compounds / metabolism
Substances
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Antineoplastic Agents
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DNA, Superhelical
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Organoplatinum Compounds
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Sulfhydryl Compounds
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carbene
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Methane