An ultrasensitive electrochemical biosensor for detection of DNA species related to oral cancer based on nuclease-assisted target recycling and amplification of DNAzyme

Chem Commun (Camb). 2011 Jul 28;47(28):8004-6. doi: 10.1039/c1cc11929j. Epub 2011 Jun 14.

Abstract

A simple, label-free, ultra-highly sensitive and selective electrochemical sensor based on nuclease-assisted target recycling and DNAzyme for the detection of DNA species related to oral cancer in saliva is developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biosensing Techniques / methods*
  • DNA / analysis*
  • DNA / genetics
  • DNA Probes / genetics
  • DNA, Catalytic / metabolism*
  • Deoxyribonucleases / metabolism*
  • Electrochemistry
  • Mouth Neoplasms / genetics*
  • Neoplasm Proteins / genetics*
  • Nucleic Acid Amplification Techniques / methods*
  • Saliva / metabolism

Substances

  • DNA Probes
  • DNA, Catalytic
  • Neoplasm Proteins
  • DNA
  • Deoxyribonucleases