Abstract
We describe here 4 patients with Sézary syndrome masquerading as adult-onset atopic dermatitis. The patients presented with a clinical picture compatible with wide-spread atopic dermatitis and did not fulfil the criteria for Sézary syndrome (lack of lymphoadenopathy and blood involvement, skin histology without presence of atypical cells). In our patients, overt Sézary syndrome developed after immunosuppressive treatment (including cyclosporine). These cases support the validity of the concept of pre-Sézary syndrome, which is a long-lasting, pre-malignant condition, and which may develop to true malignancy in a state of immunosuppression.
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biopsy
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Cyclosporine / adverse effects*
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Dermatitis, Atopic / diagnosis
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Dermatitis, Atopic / drug therapy*
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Dermatitis, Atopic / immunology
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Dermatitis, Atopic / pathology
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Diagnostic Errors
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Female
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Humans
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Immunosuppressive Agents / adverse effects*
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Male
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Middle Aged
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Precancerous Conditions / diagnosis
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Precancerous Conditions / drug therapy
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Precancerous Conditions / immunology*
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Precancerous Conditions / pathology
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Predictive Value of Tests
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Sezary Syndrome / diagnosis
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Sezary Syndrome / drug therapy
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Sezary Syndrome / immunology*
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Sezary Syndrome / pathology
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Skin / drug effects
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Skin / immunology*
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Skin / pathology
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Skin Neoplasms / diagnosis
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Skin Neoplasms / drug therapy
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Skin Neoplasms / immunology*
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Skin Neoplasms / pathology
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Treatment Outcome
Substances
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Immunosuppressive Agents
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Cyclosporine