Activation of the immune system and sperm DNA fragmentation are associated with idiopathic oligoasthenoteratospermia in men with couple subfertility

Fiore Pelliccione; Anatolia d'Angeli; Benedetta Cinque; Stefano Falone; Alessandro Micillo; Felice Francavilla; Fernanda Amicarelli; Loredana Gandini; Sandro Francavilla

doi:10.1016/j.fertnstert.2011.05.026

Activation of the immune system and sperm DNA fragmentation are associated with idiopathic oligoasthenoteratospermia in men with couple subfertility

Fertil Steril. 2011 Jun 30;95(8):2676-9.e1-3. doi: 10.1016/j.fertnstert.2011.05.026.

Authors

Fiore Pelliccione¹, Anatolia d'Angeli, Benedetta Cinque, Stefano Falone, Alessandro Micillo, Felice Francavilla, Fernanda Amicarelli, Loredana Gandini, Sandro Francavilla

Affiliation

¹ Andrology Unit, Department of Internal Medicine, University of l'Aquila, l'Aquila, Italy.

PMID: 21704215
DOI: 10.1016/j.fertnstert.2011.05.026

Abstract

Ejaculates from men without known causes for male subfertility and asymptomatic for genital tract inflammation showed infiltration of macrophages, and their activation state (HLA-DR(+)) was negatively correlated with semen parameters and positively correlated with sperm DNA damage. An activation of the immune system is thus detectable in idiopathic oligoasthenoteratozoospermia of unknown origin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
DNA Fragmentation*
Female
HLA-DR Antigens / immunology
Humans
Immunity, Innate*
Infertility, Male / etiology*
Infertility, Male / immunology
Infertility, Male / pathology
Italien
Macrophage Activation*
Macrophages / immunology*
Male
Middle Aged
Semen / cytology
Semen / immunology
Spermatozoa / pathology*

Substances

HLA-DR Antigens