Abstract
A novel 6/8/6-membered taxane with a rare C-12(13)-double bond and rare 2(3→20)abeotaxane were isolated from the needles of Taxus canadensis. Their structures were characterized as 7β,9α,10β-triacetoxytaxa-4(20),12-diene-2α,5α,11β-triol (1) and 2α,7β,10β-triacetoxy-5α-hydroxy-2(3→20)abeotaxa-4(20),11-diene-9,13-dione (2) on the basis of 1D and 2D spectroscopic data. 1 is the first example of a natural taxane without substitution at both C-13 and C-14.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / analysis*
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / isolation & purification
-
Antineoplastic Agents / pharmacology
-
Breast Neoplasms / drug therapy
-
Breast Neoplasms / pathology
-
Cell Line, Tumor
-
Female
-
Humans
-
Magnetic Resonance Spectroscopy
-
Male
-
Molecular Structure
-
Plant Extracts / analysis*
-
Plant Extracts / chemistry
-
Plant Extracts / isolation & purification
-
Plant Extracts / pharmacology
-
Plant Leaves / chemistry
-
Prostatic Neoplasms / drug therapy
-
Prostatic Neoplasms / pathology
-
Taxoids / analysis*
-
Taxoids / chemistry
-
Taxoids / isolation & purification
-
Taxoids / pharmacology
-
Taxus / chemistry*
-
Treatment Failure
-
Uterine Cervical Neoplasms / drug therapy
-
Uterine Cervical Neoplasms / pathology
Substances
-
Antineoplastic Agents
-
Plant Extracts
-
Taxoids