Sesquiterpenoids and lignans from the roots of Valeriana officinalis L

Chem Biodivers. 2011 Oct;8(10):1908-13. doi: 10.1002/cbdv.201000247.

Abstract

Two new guaiane-type sesquiterpenoids, valerol A (1) and kessyl 3-acetate (2), together with nine known compounds, valeracetate (3), anismol A (4), orientalol C (5), spatulenol (6), 4α,10α-epoxyaromadendrane (7), (+)-8-hydroxypinoresinol (8), pinorespiol (9), pinoresinol 4-O-β-D-glucopyranoside (10), and 8-hydroxypinoresinol 4'-O-β-D-glucopyranoside (11) were isolated from the roots of Valeriana officinalis. The structures and relative configurations of 1 and 2 were elucidated on the basis of spectroscopic methods (1D- and 2D-NMR, MS, UV, and IR). These compounds were evaluated for inhibitory activity on acetylcholinesterase (AChE) and enhancing activity on nerve growth factor (NGF)-mediated neurite outgrowth in PC12 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology
  • Drug Evaluation, Preclinical
  • Glucosides / chemistry
  • Lignans / chemistry*
  • Lignans / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Nerve Growth Factor / physiology
  • Neurites / drug effects
  • PC12 Cells
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Rats
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes, Guaiane / chemistry
  • Valerian / chemistry*

Substances

  • 8-hydroxypinoresinol
  • Cholinesterase Inhibitors
  • Glucosides
  • Lignans
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane
  • pinoresinol 4-O-glucopyranoside
  • Nerve Growth Factor