Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

Proteins. 2012 Feb;80(2):655-60. doi: 10.1002/prot.23208. Epub 2011 Nov 17.
No abstract available

Keywords: DNA binding; T-box proteins; crystal structure; patient mutations; protein-DNA interaction; transcription factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Crystallography, X-Ray
  • DNA / metabolism*
  • DiGeorge Syndrome / genetics
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation
  • Protein Folding
  • Protein Multimerization
  • Protein Structure, Tertiary
  • T-Box Domain Proteins / chemistry*
  • T-Box Domain Proteins / genetics
  • T-Box Domain Proteins / metabolism*

Substances

  • T-Box Domain Proteins
  • TBX1 protein, human
  • DNA

Associated data

  • PDB/4A04