Abstract
Analysis of five CTX-M-2-producing Proteus mirabilis isolates in Japan demonstrated that bla(CTX-M-2) was located on the chromosome in four isolates and on IncT plasmids in three isolates, including two isolates that also carried the gene on the chromosome. In all four isolates with chromosomal bla(CTX-M-2), ISEcp1 was responsible for the integration of the gene into the chromosome. Three different sites in the P. mirabilis genomic sequence were utilized as integration sites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology
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Chromosomes, Bacterial / genetics*
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Conjugation, Genetic / genetics*
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DNA, Bacterial / genetics
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Drug Resistance, Bacterial
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Electrophoresis, Gel, Pulsed-Field
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Humans
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Japan / epidemiology
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Plasmids / genetics*
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Proteus Infections / epidemiology
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Proteus Infections / microbiology
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Proteus mirabilis / drug effects
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Proteus mirabilis / enzymology
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Proteus mirabilis / genetics*
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Proteus mirabilis / isolation & purification
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Sequence Analysis, DNA
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beta-Lactamases / genetics*
Substances
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Anti-Bacterial Agents
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DNA, Bacterial
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beta-lactamase CTX-2
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beta-Lactamases
Associated data
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GENBANK/AB543698
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GENBANK/AB543699
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GENBANK/AB543700
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GENBANK/AB543701