Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs

Sang-Hoon Kim; Sang-Heon Kim; Jae-Hyung Lee; Byoung-Hoon Lee; Youn-Seup Kim; Jae-Seuk Park; Young-Koo Jee

doi:10.1016/j.tube.2011.09.007

Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs

Tuberculosis (Edinb). 2012 Jan;92(1):100-4. doi: 10.1016/j.tube.2011.09.007. Epub 2011 Dec 16.

Authors

Sang-Hoon Kim¹, Sang-Heon Kim, Jae-Hyung Lee, Byoung-Hoon Lee, Youn-Seup Kim, Jae-Seuk Park, Young-Koo Jee

Affiliation

¹ Department of Internal Medicine, Eulji University College of Medicine, Hagye-dong 280-1, Nowon-gu, Seoul, Republic of Korea.

PMID: 22178260
DOI: 10.1016/j.tube.2011.09.007

Abstract

Unusual drug accumulation is a common mechanism underlying serious drug-induced liver injury. Polymorphisms in three drug transporter genes (ABCB1, SLCO1B1 and ABCC2) may be risk markers for hepatitis induced by the unusual accumulation of anti-tuberculosis drugs (ATDs). We therefore investigated whether polymorphisms and haplotypes of these genes are associated with ATD-induced hepatitis by comparing the frequencies and distributions of single nucleotide polymorphisms and haplotypes of these three drug transporter genes among 67 patients with ATD-induced hepatitis and 159 patients tolerant to ATDs using a multivariate logistic regression analysis. We found that the frequencies of polymorphisms and haplotypes of ABCB1, SLCO1B1 and ABCC2 were similar in patients with ATD-induced hepatitis and ATD-tolerant controls. The present results suggest that these drug transporters do not play important roles in the pathogenesis of ATD-induced hepatitis in Korean patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
Adolescent
Adult
Aged
Aged, 80 and over
Antitubercular Agents / administration & dosage
Antitubercular Agents / adverse effects*
Asian People / genetics
Chemical and Drug Induced Liver Injury / epidemiology
Chemical and Drug Induced Liver Injury / genetics*
Female
Humans
Liver-Specific Organic Anion Transporter 1
Male
Middle Aged
Multidrug Resistance-Associated Protein 2
Multidrug Resistance-Associated Proteins / genetics*
Organic Anion Transporters / genetics*
Polymorphism, Single Nucleotide*
Republic of Korea / epidemiology
Risk Factors
Tuberculosis, Pulmonary / drug therapy*
Tuberculosis, Pulmonary / epidemiology
Tuberculosis, Pulmonary / genetics
Young Adult

Substances

ABCB1 protein, human
ABCC2 protein, human
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Antitubercular Agents
Liver-Specific Organic Anion Transporter 1
Multidrug Resistance-Associated Protein 2
Multidrug Resistance-Associated Proteins
Organic Anion Transporters
SLCO1B1 protein, human