Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality

Clin Infect Dis. 2012 Mar 1;54(5):701-5. doi: 10.1093/cid/cir926. Epub 2012 Jan 11.

Abstract

Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Load
  • Bacterial Proteins / cerebrospinal fluid
  • Cerebrospinal Fluid / microbiology
  • Humans
  • Meningitis, Pneumococcal / cerebrospinal fluid*
  • Meningitis, Pneumococcal / mortality*
  • Neuraminidase / cerebrospinal fluid
  • Streptolysins / cerebrospinal fluid*

Substances

  • Bacterial Proteins
  • Streptolysins
  • plY protein, Streptococcus pneumoniae
  • Neuraminidase