Abstract
Acyclovir pharmacokinetics was evaluated in 68 HIV-seronegative, herpes simplex virus 2 (HSV-2)-seropositive African women, who received a single oral 400-mg dose of acyclovir, with plasma acyclovir concentrations measured over 8 h. Geometric mean peak concentration and area under the concentration-time curve were 0.31 μg/ml and 1.59 h · μg/ml, respectively, 54% and 52% lower than values from non-Africans. Lower acyclovir concentrations may partly explain the reduced acyclovir suppression of HSV-2 genital ulcer recurrence in HPTN 039 African women participants.
MeSH terms
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Acyclovir / blood
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Acyclovir / pharmacokinetics*
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Administration, Oral
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Adolescent
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Adult
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Antiviral Agents / blood
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Antiviral Agents / pharmacokinetics*
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Area Under Curve
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Biological Availability
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Black People*
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DNA, Viral / biosynthesis*
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Female
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Genitalia, Female
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HIV Seronegativity
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Herpes Genitalis / blood*
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Herpes Genitalis / drug therapy
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Herpes Genitalis / ethnology
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Herpes Genitalis / virology
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Herpesvirus 2, Human / drug effects
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Herpesvirus 2, Human / physiology
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Humans
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Middle Aged
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Südafrika
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Sambia
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Simbabwe
Substances
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Antiviral Agents
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DNA, Viral
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Acyclovir