Gating neural development and aging via nuclear pores

Cell Res. 2012 Aug;22(8):1212-4. doi: 10.1038/cr.2012.35. Epub 2012 Mar 13.

Abstract

Emerging evidence suggests an involvement of nuclear pore components in the regulation of neural differentiation and aging. These findings will have far-ranging impacts on the understanding of the function of the nuclear envelope in physiological settings and in various neurological diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cellular Senescence*
  • Mice
  • Neurogenesis*
  • Neurons / metabolism
  • Neurons / physiology*
  • Nitric Oxide / metabolism
  • Nuclear Envelope / metabolism
  • Nuclear Envelope / physiology
  • Nuclear Pore / metabolism
  • Nuclear Pore / physiology*
  • Nuclear Pore Complex Proteins / metabolism
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism

Substances

  • Nuclear Pore Complex Proteins
  • Nup210 protein, mouse
  • Reactive Oxygen Species
  • Nitric Oxide