Abstract
Sickle cell disease (SCD) is a common monogenetic disorder with high associated morbidity and mortality. The pulmonary complications of SCD are of particular importance, as acute chest syndrome and pulmonary hypertension have the highest associated mortality rates within this population. This article reviews the pathophysiology, diagnosis, and treatment of clinically significant pulmonary manifestations of SCD, including acute chest syndrome, asthma, and pulmonary hypertension in adult and pediatric patients. Clinicians should be vigilant in screening and treating such comorbidities to improve patient outcomes.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acute Chest Syndrome / diagnostic imaging
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Acute Chest Syndrome / epidemiology*
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Acute Chest Syndrome / therapy
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Adolescent
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Adult
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Anemia, Sickle Cell / diagnosis
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Anemia, Sickle Cell / epidemiology*
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Anemia, Sickle Cell / therapy
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Asthma / diagnostic imaging
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Asthma / epidemiology*
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Asthma / therapy
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Child
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Comorbidity
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Disease Progression
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Female
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Humans
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Hypertension, Pulmonary / diagnostic imaging
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Hypertension, Pulmonary / epidemiology*
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Hypertension, Pulmonary / therapy
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Male
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Middle Aged
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Prognosis
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Radiography
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Risk Assessment
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Severity of Illness Index
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Survival Analysis
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Young Adult