Decreased hepcidin expression in murine β-thalassemia is associated with suppression of Bmp/Smad signaling

Blood. 2012 Mar 29;119(13):3187-9. doi: 10.1182/blood-2012-01-405563.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimicrobial Cationic Peptides / genetics*
  • Antimicrobial Cationic Peptides / metabolism
  • Bone Morphogenetic Protein 6 / genetics
  • Bone Morphogenetic Protein 6 / metabolism
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Bone Morphogenetic Proteins / physiology*
  • Down-Regulation / genetics
  • Gene Expression Regulation
  • Hepcidins
  • Iron / metabolism
  • Iron Overload / genetics
  • Iron Overload / metabolism
  • Liver / metabolism
  • Liver / pathology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Signal Transduction / genetics
  • Signal Transduction / physiology
  • Smad Proteins / genetics
  • Smad Proteins / metabolism
  • Smad Proteins / physiology*
  • beta-Thalassemia / genetics*
  • beta-Thalassemia / metabolism
  • beta-Thalassemia / pathology

Substances

  • Antimicrobial Cationic Peptides
  • Bmp6 protein, mouse
  • Bone Morphogenetic Protein 6
  • Bone Morphogenetic Proteins
  • Hamp protein, mouse
  • Hepcidins
  • Smad Proteins
  • Iron