Abstract
Here we report that Th2 cytokines increase kallikrein 7 expression and function in keratinocytes. Our finding describes a link between the Th2 environment and epidermal barrier dysfunction in atopic dermatitis.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Cells, Cultured
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Cytokines / immunology
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Dermatitis, Atopic / immunology*
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Dermatitis, Atopic / physiopathology*
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Humans
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Interleukin-13 / immunology*
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Interleukin-4 / immunology*
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Kallikreins / genetics
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Kallikreins / metabolism*
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Keratinocytes / immunology
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Keratinocytes / metabolism
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Th2 Cells / immunology*
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Up-Regulation
Substances
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Cytokines
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Interleukin-13
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Interleukin-4
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KLK7 protein, human
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Kallikreins