Abstract
This report explains how our studies of asthma and Th2 inflammation led us to investigate the roles of chitinase-like proteins (CLPs) in lung injury and repair and puts forth an overall hypothesis that can explain the roles that these moieties play in biology and a hypothesis regarding the ways that dysregulated CLP expression may contribute to the pathogenesis of a variety of diseases. We test this hypothesis by assessing the contributions of the CLP breast regression protein (BRP)-39 in the pathogenesis of malignant melanoma metastasis to the lung.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adipokines / metabolism*
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Animals
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Biomarkers, Tumor / metabolism*
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Chitinase-3-Like Protein 1
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Glycoproteins / metabolism
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Humans
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Inflammation / metabolism*
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Lectins / metabolism*
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Lung Injury / metabolism*
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Lung Neoplasms / metabolism*
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Lung Neoplasms / secondary*
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Melanoma / metabolism*
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Melanoma / pathology
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Melanoma, Experimental / metabolism
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Melanoma, Experimental / pathology
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Mice
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Mice, Transgenic
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Neoplasm Metastasis
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Skin Neoplasms / metabolism*
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Skin Neoplasms / pathology
Substances
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Adipokines
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Biomarkers, Tumor
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CHI3L1 protein, human
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Chil1 protein, mouse
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Chitinase-3-Like Protein 1
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Glycoproteins
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Lectins