On the basis of authentic references from the literature of ayurveda and on our own observations, Puskara-Guggulu, a combination of oleoresin of C. mukul and I-recemosa, has been clinically tried on a series of ECG proved 50 patients of ischaemic heart disease. This has been administered in the dose of 6 gms per day, in three divided doses upto a period of four months. Precordial pain, discomfort and dyspnoea on effort have been controlled. Mean Serum cholesterol has been found to be decreased by 17.47%. Apart from that, marked improved in the E. C. G. pattern in 30% cases has been recorded in terms of ST-segment and T wave changes, On the whole the result was cured 10% relieved 60%, improved 20% and unchanged 10%, offering a great hope for the prevention and cure of ischaemic heart disease.