Abstract
A new benzophenone C-glycoside, malaferin A (1), and two new epicatechin derivatives, malaferin B (2) and malaferin C (3), together with five known compounds were isolated from Malania oleifera. In addition, (-)-epicatechin-3-O-benzoate (6) was isolated for the first time from a natural resource. Structures of 1-3 were determined on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. All of the compounds were evaluated for anti-HIV activities.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Benzophenones / chemistry
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Benzophenones / isolation & purification*
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Benzophenones / pharmacology
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Catechin / analogs & derivatives*
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Catechin / chemistry
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Catechin / isolation & purification
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Catechin / pharmacology
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Cell Line
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Glycosides / chemistry
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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HIV-1 / drug effects*
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Humans
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Molecular Structure
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Olacaceae / chemistry*
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification*
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Plant Extracts / pharmacology
Substances
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Anti-HIV Agents
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Benzophenones
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Glycosides
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Plant Extracts
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malaferin A
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malaferin B
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malaferin C
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Catechin