Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

So Jin Lee; Myung Sook Huh; Seung Young Lee; Solki Min; Seulki Lee; Heebeom Koo; Jun-Uk Chu; Kyung Eun Lee; Hyesung Jeon; Yongseok Choi; Kuiwon Choi; Youngro Byun; Seo Young Jeong; Kinam Park; Kwangmeyung Kim; Ick Chan Kwon

doi:10.1002/anie.201201390

Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment

Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7203-7. doi: 10.1002/anie.201201390. Epub 2012 Jun 13.

Authors

So Jin Lee¹, Myung Sook Huh, Seung Young Lee, Solki Min, Seulki Lee, Heebeom Koo, Jun-Uk Chu, Kyung Eun Lee, Hyesung Jeon, Yongseok Choi, Kuiwon Choi, Youngro Byun, Seo Young Jeong, Kinam Park, Kwangmeyung Kim, Ick Chan Kwon

Affiliation

¹ Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul 136-791, Korea.

PMID: 22696263
DOI: 10.1002/anie.201201390

Abstract

The condensed version: Thiolated glycol chitosan can form stable nanoparticles with polymerized siRNAs through charge-charge interactions and self-cross-linking (see scheme). This poly-siRNA/glycol chitosan nanoparticles (psi-TGC) provided sufficient in vivo stability for systemic delivery of siRNAs. Knockdown of tumor proteins by psi-TGC resulted in a reduction in tumor size and vascularization.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Chitosan / chemistry*
Genetic Therapy
Humans
Mice
Nanoparticles / chemistry*
Neoplasms / genetics
Neoplasms / pathology
Neoplasms / therapy*
RNA Interference*
RNA, Small Interfering / administration & dosage*
RNA, Small Interfering / genetics
RNA, Small Interfering / therapeutic use*
Sulfhydryl Compounds / chemistry
Vascular Endothelial Growth Factor A / genetics

Substances

RNA, Small Interfering
Sulfhydryl Compounds
Vascular Endothelial Growth Factor A
glycol-chitosan
Chitosan