Abstract
Growth of normal diploid mammalian cells in vitro is strongly regulated by the actual cell density. Cell-cell contacts via specific plasma membrane glycoproteins whose glycan moieties interact with specific receptors has been found to be a main growth regulatory principle. Malignant growth is suggested to result from impaired function of these receptors.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cell Adhesion / physiology
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Cell Aggregation / physiology
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Cell Communication / physiology*
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Cell Division / physiology*
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Contact Inhibition / physiology
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Humans
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Platelet Membrane Glycoproteins / chemistry
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Platelet Membrane Glycoproteins / physiology*
Substances
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Platelet Membrane Glycoproteins