3,4-Dihydroxycinnamic acid attenuates the fatigue and improves exercise tolerance in rats

Biosci Biotechnol Biochem. 2012;76(5):1025-7. doi: 10.1271/bbb.111006. Epub 2012 May 7.

Abstract

3,4-Dihydroxycinnamic acid (3,4-DA) is a natural compound with high antioxidant potential found in various foods. This study found that animals administered with 3,4-DA had higher exercise tolerance, reduced blood lactate, and markers of hepatic oxidation. Blood glucose and antioxidant enzymes were not affected by this treatment. 3,4-DA may have applicability in reducing the fatigue associated with exercise.

MeSH terms

  • Administration, Oral
  • Animals
  • Antioxidants / administration & dosage*
  • Blood Glucose / analysis
  • Caffeic Acids / administration & dosage*
  • Exercise Tolerance / drug effects*
  • Exercise Tolerance / physiology
  • Fatigue / metabolism
  • Fatigue / prevention & control*
  • Lactates / blood
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Oxidative Stress / drug effects
  • Physical Conditioning, Animal
  • Rats
  • Rats, Wistar

Substances

  • Antioxidants
  • Blood Glucose
  • Caffeic Acids
  • Lactates
  • caffeic acid