Abstract
Neoadenoloside A (1), an unprecedented diterpene C-glycoside with a unique C(26) framework, along with lasiokaurin (3) were isolated from the leaves of Isodon adenolomus. The absolute configuration of 2, a derivative of 1, was determined by spectroscopic methods and single-crystal X-ray diffraction analysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line, Tumor
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Cell Survival / drug effects
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Crystallography, X-Ray
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Glycosides / isolation & purification*
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Glycosides / pharmacology
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Humans
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Inhibitory Concentration 50
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Isodon / chemistry*
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Plant Leaves / chemistry*
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Spectrometry, Mass, Electrospray Ionization
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Glycosides
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lasiokaurin