Abstract
The Stevens rearrangement of a nitrile-stabilized ammonium ylide is the key step of a very short and practical synthesis of the phenanthroindolizine alkaloid (±)-tylophorine. The method requires only five linear steps and is devoid of any protecting group manipulations.
MeSH terms
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Alkaloids / chemical synthesis*
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Alkaloids / chemistry
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Indolizines / chemical synthesis*
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Indolizines / chemistry
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Molecular Structure
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Nitriles / chemistry*
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Phenanthrenes / chemical synthesis*
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Phenanthrenes / chemistry
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Quaternary Ammonium Compounds / chemistry*
Substances
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Alkaloids
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Indolizines
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Nitriles
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Phenanthrenes
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Quaternary Ammonium Compounds
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tylophorine