Clinical and cytogenetic characteristics of myelodysplastic syndrome in patients with HIV infection

Leuk Res. 2012 Nov;36(11):1376-9. doi: 10.1016/j.leukres.2012.08.003. Epub 2012 Aug 21.

Abstract

We report eight patients of myelodysplastic syndrome (MDS) with HIV infection. Compared to a historical cohort of HIV-uninfected MDS patients, HIV/MDS were younger (p=0.019), had more complex cytogenetics (p=0.015), and more often had 7q deletion or monosomy 7 (p=0.011). In five patients, HIV/MDS transformed to acute myeloid leukemia, with a median time to transformation of 7 months. Also, the median overall survival was shorter in the HIV/MDS than in their HIV-uninfected counterparts (8 vs. 22 months; p=0.003). These results suggest that HIV/MDS is a high-risk MDS necessitating thorough cytogenetic analysis and follow-up.

MeSH terms

  • Adult
  • Aged
  • Cell Transformation, Neoplastic / genetics
  • Female
  • HIV Infections / complications*
  • HIV Infections / genetics*
  • HIV Infections / mortality
  • Humans
  • In Situ Hybridization, Fluorescence
  • Kaplan-Meier Estimate
  • Leukemia, Myeloid, Acute / etiology
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / complications*
  • Myelodysplastic Syndromes / genetics*
  • Myelodysplastic Syndromes / mortality
  • Prognosis