Abstract
Cervical shedding of HIV-1 DNA may influence HIV-1 sexual transmission. HIV-1 DNA was detected in 250 (80%) of 316 and 207 (79%) of 259 cervical cytobrush specimens from 56 US and 80 Kenyan women, respectively. Plasma HIV-1 RNA concentration was associated with increased HIV-1 DNA shedding among US and Kenyan women. Kenyan women had higher cervicovaginal concentrations of proinflammatory interleukins (IL)-1β, IL-6, IL-8, and anti-inflammatory secretory leukocyte protease inhibitor compared with US women (all P < 0.01). HIV-1 DNA shedding was associated with increased concentrations of IL-1β and IL-6 and lower secretory leukocyte protease inhibitor among US women but not Kenyan women.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Anti-Retroviral Agents / therapeutic use
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CD4 Lymphocyte Count
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Cervix Uteri / metabolism
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Cervix Uteri / virology*
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Cytomegalovirus Infections / complications
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DNA, Viral / isolation & purification*
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Female
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HIV Infections / complications
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HIV Infections / drug therapy
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HIV Infections / virology*
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HIV-1 / isolation & purification*
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Herpes Genitalis / complications
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Humans
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Interleukin-1 / metabolism
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Interleukin-1beta / metabolism
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Interleukin-8 / metabolism
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Kenia
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Middle Aged
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Prospective Studies
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RNA, Viral / blood
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RNA, Viral / isolation & purification
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Reproductive Tract Infections / complications
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Reproductive Tract Infections / microbiology
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Reproductive Tract Infections / virology
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Vereinigte Staaten
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Uterine Cervicitis / complications
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Uterine Cervicitis / metabolism
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Vagina / metabolism
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Vagina / microbiology
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Vagina / virology*
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Vaginitis / complications
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Vaginitis / metabolism
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Vaginitis / microbiology
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Viral Load
Substances
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Anti-Retroviral Agents
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DNA, Viral
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Interleukin-1
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Interleukin-1beta
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Interleukin-8
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RNA, Viral