Long-term treatment with linezolid in a patient with osteomyelitis undergoing hemodialysis

J Chemother. 2012 Aug;24(4):226-8. doi: 10.1179/1973947812Y.0000000014.

Abstract

Anemia and/or thrombocytopenia are the most relevant adverse effects of linezolid treatment. We report the case of a patient under hemodialysis who developed osteomyelitis involving the amputation stump of the left limb due to a vancomycin-resistant and teicoplanin-resistant Enterococcus faecium successfully treated with linezolid for 6 months. Close monitorization of the patient probably contributed to maintenance of treatment with linezolid despite hematological alterations observed, which could be attributed to either the underlying patient's clinical condition or antimicrobial treatment.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / administration & dosage
  • Acetamides / adverse effects
  • Acetamides / therapeutic use*
  • Amputation Stumps / microbiology
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Monitoring
  • Drug Resistance, Multiple, Bacterial
  • Enterococcus faecium / drug effects
  • Enterococcus faecium / isolation & purification
  • Gram-Positive Bacterial Infections / complications
  • Gram-Positive Bacterial Infections / drug therapy*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / therapy*
  • Linezolid
  • Male
  • Middle Aged
  • Osteomyelitis / complications
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology
  • Oxazolidinones / administration & dosage
  • Oxazolidinones / adverse effects
  • Oxazolidinones / therapeutic use*
  • Renal Dialysis*
  • Time Factors
  • Treatment Outcome

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid