Abstract
Children with sickle cell anaemia (SCA) might carry hospital-associated bacterial lineages due to frequent hospital stays and antibiotic treatments. In this study we compared Staphylococcus aureus from SCA patients (n=73) and healthy children (n=143) in a cross-sectional study in Gabon. S. aureus carriage did not differ between children with SCA (n=34, 46∙6%) and controls matched for age, residence and sex (n=67, 46∙9%). Both groups shared similar S. aureus genotypes. This finding points towards a transmission of S. aureus between both groups in the community. We conclude that resistance rates from population-based studies with healthy participants could therefore also be used to guide treatment and prophylaxis of endogenous infections in children with SCA despite a different selection pressure.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anemia, Sickle Cell / complications*
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Anemia, Sickle Cell / epidemiology
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Anti-Bacterial Agents / pharmacology*
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Bacterial Toxins / genetics*
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Bacterial Toxins / metabolism
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Bacterial Typing Techniques
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Case-Control Studies
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Child
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Child, Preschool
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Cross-Sectional Studies
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Drug Resistance, Bacterial*
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Exotoxins / genetics*
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Exotoxins / metabolism
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Female
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Gabon / epidemiology
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Humans
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Leukocidins / genetics*
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Leukocidins / metabolism
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Male
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Multilocus Sequence Typing
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Polymerase Chain Reaction
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Risk Factors
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Staphylococcal Infections / complications*
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Staphylococcal Infections / epidemiology
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Staphylococcal Protein A / genetics
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Staphylococcal Protein A / metabolism
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Staphylococcus aureus / classification*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / genetics
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Staphylococcus aureus / metabolism
Substances
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Anti-Bacterial Agents
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Bacterial Toxins
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Exotoxins
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Leukocidins
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Panton-Valentine leukocidin
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Staphylococcal Protein A