Antifungal susceptibility to amphotericin B, fluconazole, voriconazole, and flucytosine in Candida bloodstream isolates from 15 tertiary hospitals in Korea

Ann Lab Med. 2012 Nov;32(6):426-8. doi: 10.3343/alm.2012.32.6.426. Epub 2012 Oct 17.

Abstract

The in vitro antifungal susceptibility of 636 Candida bloodstream isolates collected from 15 tertiary hospitals in Korea was determined using the Vitek-2 yeast susceptibility system (bioMérieux, France). Overall susceptibility rates were 98.1%, 95.9%, 99.1%, and 97.3% for amphotericin B, fluconazole, voriconazole, and flucytosine, respectively. The results show that the rates of resistance to 4 antifungal drugs remain low among Candida bloodstream isolates in Korea.

Keywords: Amphotericin B; Candida; Fluconazole; Flucytosine; Voriconazole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Candida / drug effects*
  • Candida / isolation & purification
  • Candidiasis / blood
  • Candidiasis / microbiology
  • Fluconazole / pharmacology*
  • Flucytosine / pharmacology*
  • Humans
  • Microbial Sensitivity Tests
  • Pyrimidines / pharmacology*
  • Republic of Korea
  • Tertiary Care Centers
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Fluconazole
  • Flucytosine
  • Voriconazole