Abstract
The Runt-related transcription factors (RUNX) belong to an ancient family of metazoan genes involved in developmental processes. Through multiple protein-interacting partners, RUNX proteins have been implicated in diverse signaling pathways and cellular processes. The frequent inactivation of RUNX genes in cancer indicates crucial roles for RUNX in tumor suppression. This review discusses the abilities of RUNX proteins, in particular RUNX3, to integrate oncogenic signals or environmental cues and to initiate appropriate tumor suppressive responses.
Copyright © 2012 UICC.
MeSH terms
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Animals
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Cell Cycle
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Core Binding Factor Alpha 2 Subunit / analysis
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Core Binding Factor Alpha 2 Subunit / genetics
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Core Binding Factor Alpha 2 Subunit / physiology
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Core Binding Factor Alpha 3 Subunit / analysis
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Core Binding Factor Alpha 3 Subunit / genetics
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Core Binding Factor Alpha 3 Subunit / physiology
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Core Binding Factor alpha Subunits / physiology*
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Humans
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Mutation
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Neoplasms / etiology*
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Protein Processing, Post-Translational
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Protein Serine-Threonine Kinases / physiology
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Serine-Threonine Kinase 3
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Signal Transduction / physiology
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Transcription, Genetic
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Transforming Growth Factor beta / physiology
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Tumor Suppressor Protein p53 / physiology
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Wnt Signaling Pathway / physiology
Substances
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Core Binding Factor Alpha 2 Subunit
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Core Binding Factor Alpha 3 Subunit
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Core Binding Factor alpha Subunits
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Transforming Growth Factor beta
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Tumor Suppressor Protein p53
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Protein Serine-Threonine Kinases
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STK3 protein, human
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Serine-Threonine Kinase 3