[Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: 2 new cases]

M Guillén; L Madero; L Parra; C Hernández; B Herrero; F Carceller; A Lassaletta; J Sevilla

doi:10.1016/j.anpedi.2012.10.003

[Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: 2 new cases]

An Pediatr (Barc). 2013 Jun;78(6):393-7. doi: 10.1016/j.anpedi.2012.10.003. Epub 2012 Nov 21.

[Article in Spanish]

Authors

M Guillén¹, L Madero, L Parra, C Hernández, B Herrero, F Carceller, A Lassaletta, J Sevilla

Affiliation

¹ Servicio de Hemato-Oncología Pediátrica, Hospital Infantil Universitario Niño Jesús, Madrid, España. [email protected]

PMID: 23182617
DOI: 10.1016/j.anpedi.2012.10.003

Abstract

Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cells, with a variable risk of transformation to acute myeloid leukemia. Progression into acute lymphoblastic leukemia (ALL) is an extremely rare event, with very few cases published in children. In this report, we describe two cases of myelodysplastic syndromes that progressed to ALL. Moreover, we review previously reported cases of MDS transformation to acute lymphoblastic leukemia in the pediatric population whose prognosis seems to be similar to that for adults.

Publication types

Case Reports
English Abstract
Review

MeSH terms

Acute Disease
Cell Transformation, Neoplastic
Child, Preschool
Female
Humans
Male
Myelodysplastic Syndromes / complications*
Myelodysplastic Syndromes / pathology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*