Abstract
Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)--a selective serotonin reuptake inhibitor--inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Enterovirus B, Human / drug effects*
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Enterovirus B, Human / genetics
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Enterovirus B, Human / metabolism*
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Enterovirus D, Human / drug effects*
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Enterovirus D, Human / genetics
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Enterovirus D, Human / metabolism*
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Fluoxetine / pharmacology*
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Selective Serotonin Reuptake Inhibitors / pharmacology*
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Viral Nonstructural Proteins / genetics
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Viral Nonstructural Proteins / metabolism*
Substances
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Carrier Proteins
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Serotonin Uptake Inhibitors
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Viral Nonstructural Proteins
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Fluoxetine
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2C protein, viral