Abstract
Ultrasmall gadolinium based particles have been functionalized with positively charged pyridinium quaternary ammonium and labelled with (111)In. Evidence of their active targeting properties towards proteoglycans has been demonstrated in vivo after intravenous injection into rats opening thus a route to cancer imaging and therapy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Contrast Media / chemistry*
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Contrast Media / therapeutic use
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Gadolinium / chemistry*
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Heterocyclic Compounds, 1-Ring / chemistry
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Indium Radioisotopes / chemistry
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Isotope Labeling
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Knee Joint / diagnostic imaging
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Nanoparticles / chemistry*
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Nanoparticles / therapeutic use
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Neoplasms / diagnostic imaging
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Neoplasms / drug therapy
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Proteoglycans / chemistry
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Proteoglycans / metabolism
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Pyridinium Compounds / chemistry*
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Quantum Dots
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Quaternary Ammonium Compounds / chemistry
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Radionuclide Imaging
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Rats
Substances
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Contrast Media
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Heterocyclic Compounds, 1-Ring
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Indium Radioisotopes
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Proteoglycans
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Pyridinium Compounds
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Quaternary Ammonium Compounds
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1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
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Gadolinium