Context: Urinary α-GST and π-GST are renal tubular leakage markers.
Objective: To evaluate the performance characteristics of these markers for the early detection of acute kidney injury (AKI).
Materials and methods: Multicenter prospective cohort study of 252 adults undergoing cardiopulmonary bypass (CPB).
Results: AKI developed in 72 patients. The 2 h post-CPB π-GST level modestly predicted the development of AKI, including higher stages of severity, whereas α-GST did not.
Discussion: Small number of events and absence of subsequent post-operative biomarker measurements.
Conclusions: Among adults undergoing CPB, urinary π-GST outperformed α-GST for predicting AKI, but neither marker displayed good discrimination.