Abstract
The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bacterial Infections / immunology
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Bacterial Infections / metabolism
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Bacterial Infections / virology*
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DEAD Box Protein 58
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DEAD-box RNA Helicases / metabolism*
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DEAD-box RNA Helicases / physiology
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Host-Pathogen Interactions / immunology*
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Humans
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Interferon-Induced Helicase, IFIH1
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Intracellular Fluid / immunology
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Intracellular Fluid / metabolism
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Intracellular Fluid / microbiology*
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Intracellular Fluid / virology*
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Membrane Proteins / metabolism
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Membrane Proteins / physiology
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Nerve Tissue Proteins / metabolism
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Nerve Tissue Proteins / physiology
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RNA Helicases / metabolism
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RNA Helicases / physiology
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RNA Virus Infections / immunology*
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RNA Virus Infections / metabolism
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RNA Virus Infections / virology
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Receptors, Cell Surface
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Receptors, Immunologic
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Receptors, Pattern Recognition / metabolism
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Receptors, Pattern Recognition / physiology
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Signal Transduction / immunology
Substances
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Membrane Proteins
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Nerve Tissue Proteins
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Receptors, Cell Surface
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Receptors, Immunologic
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Receptors, Pattern Recognition
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Robo3 protein, mouse
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Dhx58 protein, mouse
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RIGI protein, human
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IFIH1 protein, human
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DEAD Box Protein 58
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DEAD-box RNA Helicases
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Interferon-Induced Helicase, IFIH1
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RNA Helicases