Modeling and automatic feedback control of tremor: adaptive estimation of deep brain stimulation

PLoS One. 2013 Apr 24;8(4):e62888. doi: 10.1371/journal.pone.0062888. Print 2013.

Abstract

This paper discusses modeling and automatic feedback control of (postural and rest) tremor for adaptive-control-methodology-based estimation of deep brain stimulation (DBS) parameters. The simplest linear oscillator-based tremor model, between stimulation amplitude and tremor, is investigated by utilizing input-output knowledge. Further, a nonlinear generalization of the oscillator-based tremor model, useful for derivation of a control strategy involving incorporation of parametric-bound knowledge, is provided. Using the Lyapunov method, a robust adaptive output feedback control law, based on measurement of the tremor signal from the fingers of a patient, is formulated to estimate the stimulation amplitude required to control the tremor. By means of the proposed control strategy, an algorithm is developed for estimation of DBS parameters such as amplitude, frequency and pulse width, which provides a framework for development of an automatic clinical device for control of motor symptoms. The DBS parameter estimation results for the proposed control scheme are verified through numerical simulations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Deep Brain Stimulation* / methods
  • Feedback
  • Humans
  • Models, Neurological*
  • Reproducibility of Results
  • Tremor / physiopathology*
  • Tremor / therapy*

Grants and funding

The second author was supported by the Ministry of Education, Science and Technology through the National Research Foundation of Korea (grant no. R31-20004 and MEST-2012-R1A2A2A01046411). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.