Abstract
Helicobacter pylori infection induces chronic inflammation and is the strongest known risk factor for gastric cancer. The genomes of H pylori are highly diverse and therefore bacterial virulence factors play an important role in determining the outcome of H pylori infection, in combination with host responses that are augmented by environmental and dietary risk factors. It is important to gain further understanding of the pathogenesis of H pylori infection to develop more effective treatments for this common but deadly malignancy. This review focuses on the specific mechanisms used by H pylori to drive gastric carcinogenesis.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Antigens, Bacterial / genetics
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Antigens, Bacterial / metabolism
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Bacterial Outer Membrane Proteins / genetics
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Bacterial Outer Membrane Proteins / metabolism*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Carcinogenesis* / genetics
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Carcinogenesis* / immunology
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Carcinogenesis* / pathology
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Helicobacter Infections / complications*
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Helicobacter Infections / immunology
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Helicobacter pylori*
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Humans
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Stomach Neoplasms / microbiology*
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Stomach Neoplasms / pathology
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Virulence Factors / genetics*
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Virulence Factors / metabolism
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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VacA protein, Helicobacter pylori
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Virulence Factors
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cagA protein, Helicobacter pylori