Abstract
Simultaneous multi-element imaging using NanoSIMS (nano-scale secondary ion mass spectrometry), exploiting the novel combination of (195)Pt and (15)N in platinum-am(m)ine antitumour drugs, provides information on the internalisation and subcellular localisation of both metal and ligands, and allows identification of ligand exchange.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amines / chemistry
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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MCF-7 Cells
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Molecular Structure
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Nanotechnology*
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology
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Spectrometry, Mass, Secondary Ion
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Structure-Activity Relationship
Substances
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Amines
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Antineoplastic Agents
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Organoplatinum Compounds