Sustainable mesoporous carbons as storage and controlled-delivery media for functional molecules

ACS Appl Mater Interfaces. 2013 Jun 26;5(12):5868-74. doi: 10.1021/am401661f. Epub 2013 Jun 17.

Abstract

Here, we report the synthesis of surfactant-templated mesoporous carbons from lignin, which is a biomass-derived polymeric precursor, and their potential use as a controlled-release medium for functional molecules such as pharmaceuticals. To the best of our knowledge, this is the first report on the use of lignin for chemical-activation-free synthesis of functional mesoporous carbon. The synthesized carbons possess the pore widths within the range of 2.5-12.0 nm. In this series of mesoporous carbons, our best result demonstrates a Brunauer-Emmett-Teller (BET) surface area of 418 m(2)/g and a mesopore volume of 0.34 cm(3)/g, which is twice the micropore volume in this carbon. Because of the dominant mesoporosity, this engineered carbon demonstrates adsorption and controlled release of a representative pharmaceutical drug, captopril, in simulated gastric fluid. Large-scale utilization of these sustainable mesoporous carbons in applications involving adsorption, transport, and controlled release of functional molecules is desired for industrial processes that yield lignin as a coproduct.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Captopril / chemistry
  • Captopril / pharmacokinetics
  • Carbon / chemistry*
  • Delayed-Action Preparations / chemistry*
  • Lignin / chemistry*
  • Models, Biological
  • Particle Size
  • Porosity
  • Surface-Active Agents / chemistry
  • Thermogravimetry

Substances

  • Delayed-Action Preparations
  • Surface-Active Agents
  • Carbon
  • Lignin
  • Captopril