Gemcitabine with paclitaxel therapy against mesocolic leiomyosarcoma: a case report

Anticancer Res. 2013 Jul;33(7):2929-33.

Abstract

A 65-year-old man complained of lower right abdominal pain, and an intra-abdominal mass was identified. An intra-abdominal hemorrhage was discovered during a thorough examination and emergency surgery was performed. The tumor was ruptured and was fragile, making it difficult to perform extirpation; thus, an ileocecal resection was performed. The histopathological diagnosis of the tumor was leiomyosarcoma, and recurrence was observed during the early postoperative period. The patient underwent surgery twice; each time there was a recurrence, but complete resection could not be obtained, and paclitaxel and gemcitabine chemotherapy was performed. A temporary effect was observed, and control of disease progression lasted approximately five months. Standard chemotherapy for leiomyosarcoma has not been established, but this method could become a therapeutic strategy for leiomyosarcoma.

Keywords: Leiomyosarcoma; chemotherapy; gemcitabine; mesocolic; paclitaxel; recurrence.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Deoxycytidine / administration & dosage
  • Deoxycytidine / analogs & derivatives
  • Gemcitabine
  • Humans
  • Leiomyosarcoma / drug therapy*
  • Leiomyosarcoma / pathology
  • Leiomyosarcoma / surgery
  • Male
  • Mesocolon / pathology*
  • Neoplasm Recurrence, Local / diagnosis
  • Neoplasm Recurrence, Local / drug therapy*
  • Neoplasm Recurrence, Local / surgery
  • Paclitaxel / administration & dosage
  • Prognosis

Substances

  • Deoxycytidine
  • Paclitaxel
  • Gemcitabine