The respiratory pyramid: From symptoms to disease in World Trade Center exposed firefighters

Am J Ind Med. 2013 Aug;56(8):870-80. doi: 10.1002/ajim.22171. Epub 2013 Jun 20.

Abstract

Background: This study utilizes a four-level pyramid framework to understand the relationship between symptom reports and/or abnormal pulmonary function and diagnoses of airway diseases (AD), including asthma, recurrent bronchitis and COPD/emphysema in WTC-exposed firefighters. We compare the distribution of pyramid levels at two time-points: by 9/11/2005 and by 9/11/2010.

Methods: We studied 6,931 WTC-exposed FDNY firefighters who completed a monitoring exam during the early period and at least two additional follow-up exams 9/11/2005-9/11/2010.

Results: By 9/11/2005 the pyramid structure was as follows: 4,039 (58.3%) in Level 1, no respiratory evaluation or treatment; 1,608 (23.2%) in Level 2, evaluation or treatment without AD diagnosis; 1,005 (14.5%) in Level 3, a single AD diagnosis (asthma, emphysema/COPD, or recurrent bronchitis); 279 (4.0%) in Level 4, asthma and another AD. By 9/11/2010, the pyramid distribution changed considerably, with Level 1 decreasing to 2,612 (37.7% of the cohort), and Levels 3 (N = 1,530) and 4 (N = 796) increasing to 22.1% and 11.5% of the cohort, respectively. Symptoms, spirometry measurements and healthcare utilization were associated with higher pyramid levels.

Conclusions: Respiratory diagnoses, even four years after a major inhalation event, are not the only drivers of future healthcare utilization. Symptoms and abnormal FEV-1 values must also be considered if clinicians and healthcare administrators are to accurately anticipate future treatment needs, years after initial exposure.

Keywords: World Trade Center; asthma; pulmonary function; treatment outcomes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Cost of Illness
  • Firefighters*
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Health Services / economics
  • Health Services / statistics & numerical data
  • Humans
  • Logistic Models
  • Lung Diseases, Obstructive / diagnosis*
  • Lung Diseases, Obstructive / economics
  • Lung Diseases, Obstructive / etiology
  • Lung Diseases, Obstructive / therapy
  • Male
  • Middle Aged
  • Multivariate Analysis
  • New York City
  • Occupational Diseases / diagnosis*
  • Occupational Diseases / economics
  • Occupational Diseases / etiology
  • Occupational Diseases / therapy
  • Occupational Exposure / adverse effects*
  • Prognosis
  • September 11 Terrorist Attacks*
  • Severity of Illness Index
  • Spirometry