Solitary brain metastasis as first manifestation of small-cell parotid gland carcinoma with high sensitivity to temozolomide therapy on basis of tumor O6-methylguanine-DNA-methyltransferase expression

J Clin Oncol. 2013 Aug 10;31(23):e394-7. doi: 10.1200/JCO.2012.47.5590. Epub 2013 Jun 24.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Alkylating / therapeutic use
  • Brain Neoplasms / drug therapy
  • Brain Neoplasms / enzymology
  • Brain Neoplasms / pathology
  • Brain Neoplasms / secondary*
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / enzymology
  • Carcinoma, Small Cell / pathology
  • Carcinoma, Small Cell / secondary*
  • Dacarbazine / analogs & derivatives*
  • Dacarbazine / therapeutic use
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • O(6)-Methylguanine-DNA Methyltransferase / biosynthesis*
  • Parotid Neoplasms / diagnosis
  • Parotid Neoplasms / drug therapy
  • Parotid Neoplasms / enzymology
  • Parotid Neoplasms / pathology*
  • Temozolomide

Substances

  • Antineoplastic Agents, Alkylating
  • Dacarbazine
  • O(6)-Methylguanine-DNA Methyltransferase
  • Temozolomide