Critical point fluctuations in supported lipid membranes

Faraday Discuss. 2013:161:91-111; discussion 113-50. doi: 10.1039/c2fd20119d.

Abstract

In this paper, we demonstrate that it is possible to observe many aspects of critical phenomena in supported lipid bilayers using atomic force microscopy (AFM) with the aid of stable and precise temperature control. The regions of criticality were determined by accurately measuring and calculating phase diagrams for the 2 phase L(d)-L(o) region, and tracking how it moves with temperature, then increasing the sampling density around the estimated critical regions. Compositional fluctuations were observed above the critical temperature (T(c)) and characterised using a spatial correlation function. From this analysis, the phase transition was found to be most closely described by the 2D Ising model, showing it is a critical transition. Below T(c) roughening of the domain boundaries occurred due to the reduction in line tension close to the critical point. Smaller scale density fluctuations were also detected just below T(c). At T(c), we believe we have observed fluctuations on length scales greater than 10 microm. The region of critically fluctuating 10-100 nm nanodomains has been found to extend a considerable distance above T(c) to temperatures within the biological range, and seem to be an ideal candidate for the actual structure of lipid rafts in cell membranes. Although evidence for this idea has recently emerged, this is the first direct evidence for nanoscale domains in the critical region.

MeSH terms

  • Cell Membrane / chemistry*
  • Image Processing, Computer-Assisted
  • Lipid Bilayers / chemistry*
  • Membrane Fluidity
  • Membrane Lipids / chemistry*
  • Membrane Microdomains / chemistry*
  • Microscopy, Atomic Force
  • Phosphatidylcholines / chemistry
  • Temperature

Substances

  • Lipid Bilayers
  • Membrane Lipids
  • Phosphatidylcholines
  • 1-palmitoyl-2-oleoylphosphatidylcholine