Selective amination reactions of α-nitro aryl and heteroaryl enoates

J Org Chem. 2013 Aug 16;78(16):8203-7. doi: 10.1021/jo4012859. Epub 2013 Jul 31.

Abstract

Highly functionalized tetrasubstituted alkenes were obtained by an unexpected amination reaction promoted by ethyl nosyloxycarbamate on various α-nitro aryl and heteroaryl enoates. A nitrene is likely the aminating species responsible for the observed insertion reaction leading to (E)-β-amino α-nitro enoates as the major products, regardless of the substrate configuration. The compounds, bearing two nitrogenous functional groups in different oxidation states, can be regarded as interesting synthons. In contrast, aziridination was observed for α-nitro alkyl enoates or β-nitro allylic alcohols.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemical synthesis*
  • Alkenes / chemistry
  • Amination
  • Esters / chemistry*
  • Molecular Structure
  • Nitro Compounds / chemistry*

Substances

  • Alkenes
  • Esters
  • Nitro Compounds