Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants

Huadan Ye; Xiaojing Li; Lingyan Wang; Qi Liao; Leiting Xu; Yi Huang; Liming Xu; Xuting Xu; Cheng Chen; Hangyu Wu; Yanping Le; Qiong Liu; Meng Ye; Changzheng Dong; Shiwei Duan

doi:10.1016/j.gene.2013.07.029

Genetic associations with coronary heart disease: meta-analyses of 12 candidate genetic variants

Gene. 2013 Nov 15;531(1):71-7. doi: 10.1016/j.gene.2013.07.029. Epub 2013 Jul 29.

Authors

Huadan Ye¹, Xiaojing Li, Lingyan Wang, Qi Liao, Leiting Xu, Yi Huang, Liming Xu, Xuting Xu, Cheng Chen, Hangyu Wu, Yanping Le, Qiong Liu, Meng Ye, Changzheng Dong, Shiwei Duan

Affiliation

¹ Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China; The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315000, China.

PMID: 23906684
DOI: 10.1016/j.gene.2013.07.029

Abstract

Aims: The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD).

Methods: Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012).

Results: A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR)=1.61, 95% confidence interval (CI)=1.25-2.07, P=0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD.

Conclusion: Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.

Keywords: (12/15-LOX); (95% CI); (CHD); (CNKI); (GPx); (GWAS); (MAF); (OR); (QC); 12/15-lipoxygenases; 95% confidence interval; China National Knowledge Infrastructure; Coronary heart disease; GPX1; Genome-wide association studies; Glutathione peroxidase; Meta-analysis; Minor allele frequency; Odd ratio; Polymorphism; Quality control.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Coronary Artery Disease / genetics
Coronary Disease / genetics*
Genetic Association Studies*
Genetic Variation
Humans
Odds Ratio
Polymorphism, Single Nucleotide