Abstract
Scopariusic acid (1), a new ent-clerodane-based meroditerpenoid with a unique cyclobutane ring and an unusual 1-octen-3-ol substituent, together with its biosynthetic related compound 2, were isolated from the aerial parts of Isodon scoparius. The structures of 1 and 2, including their absolute configurations, were determined by spectroscopic methods, single-crystal X-ray diffraction analysis, and chemical methods. Compound 1 showed weak cytotoxicity and moderate immunosuppressive activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Crystallography, X-Ray
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Diterpenes, Kaurane / chemistry*
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Diterpenes, Kaurane / isolation & purification*
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Diterpenes, Kaurane / pharmacology
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Drug Screening Assays, Antitumor
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Female
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HL-60 Cells
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Humans
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / isolation & purification*
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Immunosuppressive Agents / pharmacology
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Isodon / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Kaurane
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Immunosuppressive Agents
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scopariusic acid