Pd(0)-catalyzed benzylic arylation-oxidation of 4-methylquinazolines via sp3 C-H activation under air conditions

Org Biomol Chem. 2013 Oct 7;11(37):6246-9. doi: 10.1039/c3ob41488d.

Abstract

An efficient and selective Pd(0)-catalyzed sp(3) C-H bond arylation-oxidation of 4-methylquinazolines is reported. The method enables the introduction of arylketone at the benzylic position of 4-methylquinazolines without the use of an additional directing group, and atmospheric oxygen is used as the sole oxidant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Air*
  • Benzene / chemistry*
  • Catalysis
  • Molecular Structure
  • Oxidation-Reduction
  • Oxygen* / chemistry
  • Palladium / chemistry*
  • Quinazolines / chemistry*

Substances

  • 4-methylquinazoline
  • Quinazolines
  • Palladium
  • Benzene
  • Oxygen