Abstract
Adalimumab is an anti-tumor necrosis factor α (TNF-α) agent approved for the treatment of ankylosing spondylitis (AS); psoriatic arthritis; and moderate to severe cases of rheumatoid arthritis (RA), plaque psoriasis, Crohn disease, ulcerative colitis, and polyarticular juvenile idiopathic arthritis. Evidence suggests that anti-TNF-α agents may increase a patient's risk for some types of cancers, including cutaneous squamous cell carcinoma (SCC). Cutaneous nonmelanoma skin cancers (NMSCs) have occurred during treatment with etanercept, infliximab, and adalimumab in the setting of RA and psoriasis, but data related to AS are less clear. We report the case of a 29-year-old woman with AS treated with adalimumab for 2 years who developed invasive SCC of the lower lip. We advocate increased NMSC surveillance in patients undergoing treatment with anti-TNF-α agents.
MeSH terms
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Adalimumab
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Adult
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Antibodies, Monoclonal / adverse effects
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Antibodies, Monoclonal / pharmacology
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized / adverse effects*
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Antibodies, Monoclonal, Humanized / pharmacology
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Antibodies, Monoclonal, Humanized / therapeutic use
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Antirheumatic Agents / adverse effects
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Antirheumatic Agents / pharmacology
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Antirheumatic Agents / therapeutic use
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Carcinoma, Squamous Cell / chemically induced*
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Carcinoma, Squamous Cell / pathology
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Etanercept
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Female
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Humans
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Immunoglobulin G / adverse effects
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Immunoglobulin G / pharmacology
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Immunoglobulin G / therapeutic use
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Infliximab
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Lip / pathology
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Receptors, Tumor Necrosis Factor / therapeutic use
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Skin Neoplasms / chemically induced*
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Skin Neoplasms / pathology
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Spondylitis, Ankylosing / drug therapy
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Antirheumatic Agents
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Immunoglobulin G
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Receptors, Tumor Necrosis Factor
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Tumor Necrosis Factor-alpha
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Infliximab
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Adalimumab
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Etanercept