Colorectal cancer (CRC) is the third common malignant tumor worldwide and the second cause of cancer-related death. Liver metastasis is the main cause of mortality in colorectal cancer. Exploration of the mechanism and the processes of liver metastasis, and therapeutic intervention are important to improve the overall survival and the quality of life of patients with colorectal cancer. Biomarkers has been one of the hot spots in the study of colorectal cancer. More and more biomarkers are being found and warrant further study.